Vacuum therapy is widely used for the treatment of chronic and complex wounds , 
Negative pressure wound therapy, or vacuum therapy, is a therapy used to encourage wound healing. It is widely used for the treatment of chronic and complex wounds.
Although the physiological basis of its effect is not yet fully understood there is evidence data supporting its use to achieve wound healing. , 
The endoscopic vacuum-assisted wound closure systems have been proven to be an important alternative in patients with upper and lower intestinal leakage which do not respond to standard surgical treatment procedures.
The endoscopic vacuum-assisted wound closure system provides continuous wound drainage and promotes tissue granulation, decreasing the time which the wound needs
to heal and showing a high rate of leakage closure. , , ,