Chemfort™ Closed System Transfer Device

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Chemfort™ is a membrane to membrane next-generation Closed System Transfer Device based on patented Toxi-Guard® air-cleaning technology. This offers a comple portfolio of products for handling hazardous drugs with confidence.

Chemfort™ includes outstanding benefits of the Tevadaptor product family, our Toxi-Guard® patented air-cleaning technology and upgraded materials and design.

The innovative design of Chemfort™ was created around real-world use and operator feedback, enabling efficient, simple use for pharmacists, nurses and other healthcare professionals.  Chemfort™ provides compatability with all know hazardous drugs and has been included in peer-reviewed studies on device safety and efficacy 1,2



Chemfort™ Vial Adaptors

  • With Toxi-Guard® air-cleaning technology
  • Connects to a drug vial to allow drug transfer in a closed system
  • Automatic pressure equalisation allows easy drug reconstitution and withdrawal
  • Suitable for any volume of vial
  • Connect to 13 mm, 20 mm, 28 mm and 32 mm drug vials
  • Spike design is highly efficient in extracting maximum drug volume from the vial, leaving minimal residual volume, and therefore reducing drug wastage4
  • Majority of vial sizes covered with one product. This refers to the Chemfort™ Vial Adaptor 20 mm that contains a 13 mm convertor.

Chemfort™ Syringe Adaptor Lock

  • Fits standard Luer Lock syringes allowing membrane to membrane linear connection and dry disconnection5
  • Connects to all Chemfort™ products with a “click” sound providing reassurance of a connection
  • Allows transfer of drug from the vial to the IV bag or directly to the patient
  • 16G needle for easier withdrawal of viscous drugs
  • A unique patented lock system for Luer Lock syringes, that cannot be opened once locked

Chemfort™ Bag Adaptor Luer Lock (LL)

  • Fits common available IV bags and semi rigid containers using an ergonomic and comfortable spike design
  • Connection to a primary IV set through a Luer Lock connection e.g. Cyto-Set®

Chemfort™ Luer Lock Adaptor

  • Converts a Luer Lock connection to a membrane to membrane Chemfort™ connection
  • Allows direct drug administration from a syringe to the patient’s IV line, catheter or other access points
  • Helps prevent leakage and danger of exposure from hazardous drugs
  • For multiple administrations with Chemfort™ Syringe Adaptors
  • Easy to access and to clean
  • Its small size allows comfortable access to the patient’s IV line

Simplivia Catheter Adaptor

  • A Simplivia product that connects to the Chemfort™ Syringe Adaptor
  • For the administration of drugs directly into a urinary catheter
  • Converts an open catheter connection to a closed system connection


Handling of Chemfort is identical to that of Tevadaptor. These Tevadaptor demonstration videos can be used as reference for Chemfort handling.

Preparing syringes with Tevadaptor / Chemfort™

Preparing infusion bags with Tevadaptor / Chemfort™

Tevadaptor / Chemfort™ Vial Adaptor

Tevadaptor / Chemfort™ Syringe Adaptor Lock

Tevadaptor / Chemfort™ Bag Adaptor

Systemic Anti-Cancer Therapy (SACT) syringe administration using Chemfort Closed System Transfer Device


Chemfort™’s patented double membrane system ‘TOXI-GUARD®’ is located inside the Chemfort™ vial adaptor.

Chemfort™ is a Closed System Drug Transfer Device (CSTD) designed to help to prevent the escape of hazardous drug vapours into the environment during drug reconstitution and administration. Drug containment in the Chemfort™ Vial Adaptor is accomplished by the TOXI-GUARD® system, which contains a 100% activated carbon drug binding matrix and 0.2 μm hydrophobic and oleophobic membrane. The activated carbon matrix is highly efficient in adsorption of drug vapours. The 0.2 μm membrane is a sterile barrier helping to prevent micro-organisms and particles from entering the system and, due to its hydrophobic and oleophobic properties, helps to prevent aerosols and liquids from being released from the system. Together, they serve as an effective sterile, particulate and toxic drug vapour barrier.

The TOXI-GUARD® system ensures that the Chemfort™ air pathway only allows particulate and bacteria-free air to enter the drug vial during drug reconstitution and preparation. It also ensures that the air exiting the drug vial is free of hazardous drugs’ vapour.

Several studies were performed, challenging the efficacy of the Chemfort™ Vial Adaptor to prevent the escape of drug vapours6. A model system was designed to induce drug vapours within the drug vial. Since under normal usage conditions, the drug vapours that are generated are minimal, extreme conditions were employed to significantly increase vapour quantity. Vapours released from the Chemfort™ Vial Adaptor were trapped within a closed test chamber. The trapped drug was collected and then analyzed by highly sensitive LC/MS/MS methods.

The Chemfort™ Vial Adaptor was challenged with three commonly used antineoplastic drugs: Cyclophosphamide, 5-Fluorouracil and Doxorubicin. With Cyclophosphamide and 5-Fluorouracil, vapours were consistently detected in control samples in which the TOXI-GUARD® system had been removed from the Chemfort™ Vial Adaptor. In test samples containing an intact TOXI-GUARD® system, no drug vapours were detected. With Doxorubicin no drug vapours were detected in either the positive control or test sample.

These results support the validity of the Chemfort™ Vial Adaptor helps to prevent the release of hazardous drug vapours.

Click here to view further information on B. Braun CYTO-SET AIRSTOP.


  1. Chemfort data on file, White paper, Compatibility with All Known Hazardous Drugs
  2. P. Sessink et al., Validation of chemotherapy drug vapor containment of an air cleaning closed-system drug transfer device, Journal of Oncology Pharmacy Practice, 2022 Oct; 28(7):1508-1515
  3. Wilkinson A.S., Allwood MC, et al., Performance testing protocol for closed-system transfer devices used during pharmacy compounding and adminis¬tration of hazardous drugs. PLoS ONE 13(10) : e0205263, Oct 2018
  4. Juhász, Á., Batka, G. & Szűcs, A. Responding to drug shortages and rising costs: IV chemotherapy drug use optimization achieved by closed safety devices in hospital pharmacies. Drugs Ther Perspect 32, 170–176 (2016).
  5. T. Marler-Hausen et al, 2020, Use of a closed-system drug transfer device reduces contamination with doxorubicin during bolus injection, British Journal of Nursing, 2020, Vol 29, No 10
  6. Flexzorb™ Activated Carbon Cloth, Chemviron Carbon, Cloth Division, United Kingdom,