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Wound management

Wound bed preparation

Biofilm is very likely present in non-healing chronic human wounds. Awareness of this presence is as important as the knowledge of distinct phenotype differences, especially in terms of the challenge to remove and eradicate biofilm from a wound.

Prontosan® Wound Bed Preparation System​

Achieve better therapeutic cleansing outcomes with the Prontosan® system​

Wound bed preparation with the Prontosan® System mobilizes synergistic ingredients to perform a more effective cleansing than the use of saline or water alone.[6,7,16,23,24]

Trust in Pronosan® for wound bed preparation 

Prontosan® Wound Irrigation Solution

With Prontosan® we provide a concept for wound bed preparation based on a special combination of Polihexanide and Betaine. Prontosan® helps manage infection prevention, cleansing/debridement as well as wound bed moistening.

Prontosan® Debridement Pad for mechanical wound debridement

Chronic wounds mostly require repeated debridement. The Prontosan® Debridement Pad has been designed to support the wound bed preparation with Prontosan® Wound Irrigation Solution. The Pad consists of a front layer with microfibers that debride and an absorbent backing layer.

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References

  1. Percival, S. L. (2016). Importance of biofilm formation in surgical infection. Journal of Hospital Infection, 92(3), 222–227. https://doi.org/10.1016/j.jhin.2015.07.009​
  2. Millán-Reyes, M.J.; Afanador-Restrepo, D.F.; Carcelén-Fraile, M.d.C.; Aibar-Almazán, A.; Sánchez-Alcalá, M.; Cano-Sánchez, J.; Mesas-Aróstegui, M.A.; Castellote-Caballero, Y. Reducing Infections and Improving Healing in Complex Wounds: A Systematic Review and Meta-Analysis. J. Clin. Med. 2025, 14, 3237. https://doi.org/10.3390/jcm14093237[1](https://www.mdpi.com/2077-0383/14/9/3237)​
  3. International Wound Infection Institute (IWII) Therapeutic wound and skin cleansing: Clinical evidence and recommendations. Wounds International 2025.​
  4. International Wound Infection Institute. Wound Infection in Clinical Practice: Principles of Best Practice. Wounds International; 2022.​
  5. Phillips K. Sustaining Improved Patient Outcomes in the Reduction of Wound Infections. Wounds UK; 2025.​
  6. Andriessen AE, Eberlein T. Assessment of a wound cleansing solution in the treatment of problem wounds. Wounds. 2008;20(6):171-5.​
  7. Möller A, Kaehn K, Nolte A. Erfahrungen mit dem Einsatz polihexanidhaltiger Wundprodukte bei der Versorgung chronischer Wunden - Ergebnisse einer systematischen retrospektiven Untersuchung an 953 Patienten [Experiences in using polyhexanide containing wound products in the management of chronic wounds – results of a methodical and retrospective analysis of 953 cases.]. Wund Management. 2008:111-7. In German.​
  8. Ciprandi G, Ramsay S, Budkevich L, Strack A, van Capellen P, Marathovouniotis N. A retrospective systematic data review on the use of a polihexanide-containing product on burns in children. J Tissue Viability. 2018;27(4):244-8.​
  9. Kiefer J, Harati K, Müller-Seubert W, Fischer S, Ziegler B, Behr B, Gille J, Kneser U, Lehnhardt M, Daigeler A, Dragu A. Efficacy of a Gel Containing Polihexanide and Betaine in Deep Partial and Full Thickness Burns Requiring Split-thickness Skin Grafts: A Noncomparative Clinical Study. J Burn Care Res. 2018 Aug 17;39(5):685-693.​
  10. Upton D, Solowiej K. Painful Dressing Changes for Chronic Wounds: Assessment and Management. Journal of Wound Care; 2012 .​
  11. Kirkcaldy AJ, Wilson M, Cooper R, Baxter SK, Campbell F. Strategies for Reducing Pain at Dressing Change in Chronic Wounds: Protocol for a Mapping Review. BMJ Open; 2023.​
  12. Atkin L, et al. Wound bed preparation: a case series using polyhexanide and betaine solution and gel-a UK perspective. J Wound Care. 2020 Jul 2;29(7):380-386.​
  13. Bellingeri A, Falciani F, Traspedini P, Moscatelli A, Russo A, Tino G, Chiari P, Peghetti A. Effect of a wound cleansing solution on wound bed preparation and inflammation in chronic wounds: a single-blind RCT. J Wound Care. 2016 Mar;25(3):160, 162-6, 168.​
  14. Valenzuela AR, Perucho NS. The effectiveness of a 0.1% polyhexanide gel. Rev Enferm. 2008;31(4):7-12.​
  15. Eberlein T. Expert assessment: Expert assessment on the benefits of systematic application of Prontosan® solution in wound treatment with particular focus on cost-efficiency when compared to current standard treatment (saline/Ringer). 2006.​
  16. Romanelli M, Dini V, Barbanera S, Bertone MS. Evaluation of the efficacy and tolerability of a solution containing propyl betaine and polihexanide for wound irrigation. Skin Pharmacol Physiol. 2010;23 Suppl:41-4. doi: 10.1159/000318266. Epub 2010 Sep 8.​
  17. Durante CM, Greco A, Sidoli O, Maino C, Gallarini A, Ciprandi G. Evaluation of the effectiveness of a polyhexanide and propyl betaine-based gel in the treatment of chronic wounds. Minerva Chir. 2014 Oct;69(5):283-92​
  18. Horrocks A. Prontosan wound irrigation and gel: management of chronic wounds. Br J Nurs. 2006 Dec 14-2007 Jan 10;15(22):1222, 1224-8.​
  19. Ricci E. Cleansing versus tailored deep debridement, a fresh approach to wound cleansing: an Italian experience. J Wound Care. 2018 Aug 2;27(8):512-518.​
  20. Bradbury S, Fletcher J. Prontosan made easy. Wounds international. 2011;2(2):1-6.​
  21. Cooper DM, Bojke C, Ghosh P. Cost-Effectiveness of PHMB & betaine wound bed preparation compared with standard care in venous leg ulcers: A cost-utility analysis in the United Kingdom. J Tissue Viability. 2023 May;32(2):262-269.​
  22. Gansen F, Hepworth C; Richardson S; Rice C; Davidson J, Frei T; Barth C. Polihexanide and Betaine (PSGX) Containing Solution Versus Saline for the Treatment of Leg Ulcers: A Comparative Cost Analysis Using Real-World Data From England. Value in Health (2024) 27:12 Supplement (S63-S64). Date of Publication: 1 Dec 2024, ISPOR.​
  23. Oropallo, A., Rao, A. S., Del Pin, C., Ranire-Maguire, M., & Mathew, A. (2024). An objective comparative study of non-surgical cleansing techniques and cleanser types in bacterial burden management. International wound journal, 21(2), e14730.​
  24. Davis SC, Harding A, Gil J, Parajon F, Valdes J, Solis M, Higa A. Effectiveness of a polyhexanide irrigation solution on methicillin-resistant Staphylococcus aureus biofilms in a porcine wound model. Int Wound J. 2017;14(6):937-44.​
  25. International Wound Infection Institute (IWII) Therapeutic wound and skin cleansing: Clinical evidence and recommendations. Wounds International 2025.